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Hepatic transport systems
Author(s) -
FERENCI PETER,
ZOLLNER GERNOT,
TRAUNER MICHAEL
Publication year - 2002
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.17.s1.15.x
Subject(s) - medicine , cholestasis , cholestasis of pregnancy , disease , progressive familial intrahepatic cholestasis , cystic fibrosis , liver disease , bioinformatics , pregnancy , pathology , fetus , biology , genetics , transplantation , liver transplantation
The identification of the genes responsible for various genetic liver disorders lead to a better understanding of basic physiology of hepatic transport systems. In this review we focus on transport systems involved in the generation of bile and in the maintenance of copper homeostasis. Abnormal function of these transporters results in diseases like Wilson’s disease, progressive familial cholestasis syndromes, Dubin–Johnson syndrome and cystic fibrosis. Beyond these well defined diseases, functional impairments of transport proteins may predispose to non‐genetic diseases ranging from intrahepatic cholestasis of pregnancy to neurodegenerative disorders including Alzheimer’s disease.