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Experimental models linking dendritic cell lineage, phenotype and function
Author(s) -
Fazekas De St Groth Barbara,
Smith Adrian L,
Bosco Julian,
Sze Daniel MY,
Power Carl A,
Austen Felicity I
Publication year - 2002
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2002.01117.x
Subject(s) - myeloid , biology , dendritic cell , phenotype , function (biology) , cd8 , progenitor cell , microbiology and biotechnology , lineage (genetic) , progenitor , lymphopoiesis , immunology , genetics , stem cell , gene , antigen
One of the important issues in dendritic cell (DC) biology today is how DC control the fate of T cells. Our data suggest that an important branch point in determining T cell fate is the decision between deletion and memory. We have previously hypothesized that this binary decision is determined by contact with DC derived from lymphoid‐ versus myeloid‐restricted progenitors. However, the false attribution of CD8α expression as a reliable marker of lymphoid origin has underpinned a number of studies in which DC expressing CD8α did not induce deletion, thereby clouding the issue of whether deletion is indeed a function of lymphoid DC. By returning to basics, that is, functional testing of the progeny of lymphoid‐ and myeloid‐restricted progenitors in vivo , we hope to provide clear evidence of the in vivo roles of lymphoid and myeloid DC subsets, independent of assumptions about the surface phenotypes they can assume.