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Immunity to asexual blood stage malaria and vaccine approaches
Author(s) -
Wipasa Jiraprapa,
Elliott Salenna,
Xu Huji,
Good Michael F
Publication year - 2002
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2002.01107.x
Subject(s) - malaria , immunity , biology , immunology , malaria vaccine , disease , stage (stratigraphy) , medicine , virology , immune system , plasmodium falciparum , pathology , paleontology
The development of a malaria vaccine seems to be a definite possibility despite the fact that even individuals with a life time of endemic exposure do not develop sterile immunity. An effective malaria vaccine would be invaluable in preventing malaria‐associated deaths in endemic areas, especially amongst children less than 5 years of age and pregnant women. This review discusses our current understanding of immunity against the asexual blood stage of malaria − the stage that is responsible for the symptoms of the disease − and approaches to the design of an asexual blood stage vaccine.