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Biology and significance of T‐cell apoptosis in the liver
Author(s) -
Park Sun,
Murray Debbie,
John Beena,
Crispe I Nicholas
Publication year - 2002
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2002.01065.x
Subject(s) - apoptosis , biology , immune system , immunology , cd8 , hepatitis c virus , t cell , hepatitis , virology , virus , microbiology and biotechnology , cancer research , genetics
The liver has emerged as an organ with distinct immunological properties. In this review, we summarize evidence that shows that the liver can remove apoptotic, or non‐apoptotic but activated, CD8 + T cells from the circulation and induce apoptosis in these activated T cells by either active or passive mechanisms. Hepatitis viruses, particularly hepatitis C virus, often establish persistent infection. We review evidence that suggests that these viruses exploit intrahepatic tolerance mechanisms to protect themselves from immune attack.