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T‐cell survival and the role of cytokines
Author(s) -
Sprent Jonathan
Publication year - 2001
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2001.00999.x
Subject(s) - major histocompatibility complex , stimulation , microbiology and biotechnology , cell , immunology , t cell , biology , chemistry , antigen , neuroscience , immune system , biochemistry
Typical T cells are long‐lived resting cells. Despite their quiescent appearance, there is increasing evidence that T cells are subjected to continuous stimulation through contact with various stimuli, notably by self peptide/MHC complexes and cytokines. These stimuli keep T cells alive and also cause intermittent entry into cell cycle.