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Chemokine and cytokine cooperativity: Eosinophil migration in the asthmatic response
Author(s) -
Simson Ljubov,
Foster Paul S
Publication year - 2000
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2000.00922.x
Subject(s) - chemokine , eotaxin , immunology , eosinophil , allergic inflammation , microbiology and biotechnology , chemotaxis , integrin , cytokine , chemokine receptor , ccr3 , chemistry , biology , receptor , inflammation , asthma , biochemistry
Eosinophils play a central role in the pathophysiology of allergic disease. The mechanisms that regulate eosinophil migration are complex; however, chemokines and cytokines produced in both the early and late phases of the asthmatic response appear to cooperate in eosinophil recruitment. In particular, there exists a unique synergy between eotaxin and IL‐5. The role of chemokine/cytokine cooperativity has been investigated in the extracellular matrix, adhesion molecule/integrin interactions, receptor polarization and aggregation and the convergence and divergence of intracellular signalling pathways. Understanding the mechanisms whereby eosinophils migrate will allow the development of specific therapeutic strategies aimed at attenuating specific components of the allergic response.