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Associations between HLA‐DQB1 high‐risk alleles and type I diabetes do not depend on cytomegalovirus antibody status at onset: A case‐parent study conducted in Chile
Author(s) -
Santos Jl,
PérezBravo F,
Carrasco E,
Petri R,
Calvillán M,
Albala C
Publication year - 2000
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2000.00911.x
Subject(s) - hla dqb1 , allele , odds ratio , human leukocyte antigen , hla dq , antibody , confidence interval , immunology , human cytomegalovirus , biology , genetics , medicine , antigen , haplotype , virus , gene
The purpose of the present study is to ascertain whether the associations between HLA‐DQB1 ∗0201 and DQB1 ∗0302 alleles and childhood diabetes depend on the presence of antibodies to human cytomegalovirus (CMV). A study of incident type I diabetes cases and parents was conducted in Santiago, Chile. HLA‐DQB1 polymorphisms were determined in 85 case‐parent trios (255 subjects), while the detection of CMV was carried out only in the incident cases. As expected, HLA‐DQB1 polymorphisms are strongly associated with type I diabetes, with crude odds ratios of 3.7 (95% confidence interval (CI) 1.8–7.7) for the DQB1 ∗0201 allele and 10.3 (95% CI 5.0–21.4) for the DQB1 ∗0302 allele. In the subset of families with CMV+ cases, the odds ratios were estimated as 3.7 (95% CI 1.6–8.6) for the DQB1 ∗0201 allele and 11.1 (95% CI 4.8–25.8) for the DQB1 ∗0302 allele. In families with patients who tested negative for CMV antibodies, the odds ratios were calculated as 3.5 (95% CI 0.7–16.8) for the DQB1 ∗0201 allele, and 8.0 (95% CI 1.8–34.7) for the DQB1 ∗0302 allele. There was no evidence of statistical interaction between CMV antibodies and the DQB1 ∗0201 allele ( P value = 0.9) or the DQB1 ∗0302 allele ( P value = 0.7). In conclusion, alleles DQB1 ∗0302 and DQB1 ∗0201 do not display distinct associations with type I diabetes depending on the presence of antibodies for CMV.