Premium
Dendritic cells: Multiple subtypes, multiple origins, multiple functions
Author(s) -
Shortman Ken
Publication year - 2000
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2000.00901.x
Subject(s) - phenotype , dendritic cell , microbiology and biotechnology , biology , function (biology) , antigen presentation , cytokine , cd8 , immunology , immune system , t cell , gene , genetics
The dendritic cells (DC) of the mouse are surprisingly heterogeneous by surface phenotype and may be segregated based on expression of CD4 and CD8. These DC subtypes appear to differ in developmental origin and display some differences in biological function, including regulation of the cytokine production of the T cells that they activate. This presentation reviews the attempts of one laboratory to understand this complex DC system.