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Do T cells care about the mitogen‐activated protein kinase signalling pathways?
Author(s) -
Rincón Mercedes,
Conze Dietrich,
Weiss Linda,
Diehl Nicole L,
Fortner Karen A,
Yang Derek,
Flavell Richard A,
Enslen Hervè,
Whitmarsh Alan,
Davis Roger J
Publication year - 2000
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2000.00900.x
Subject(s) - mitogen activated protein kinase , microbiology and biotechnology , p38 mitogen activated protein kinases , kinase , ask1 , mapk14 , map kinase kinase kinase , mapk7 , mitogen activated protein kinase kinase , protein kinase a , biology
Mitogen‐activated protein (MAP) kinases, which include the extracellular response kinases, p38 and c‐Jun amino terminal kinases (JNK), play a significant role in mediating signals triggered by cytokines, growth factors and environmental stress. The JNK and p38 MAP kinases have been involved in growth, differentiation and cell death in different cell types. In the present paper, we describe how the JNK and p38 MAP kinase signalling pathways are regulated and their role during thymocyte development and the activation and differentiation of T cells in the peripheral immune system. The results from these studies demonstrate that the JNK and p38 MAP kinase signalling pathways regulate different aspects of T‐cell mediated immune responses.