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The anti‐idiotypic antibody 1F7 selectively inhibits cytotoxic T cells activated in HIV‐1 infection
Author(s) -
Grant Michael,
Smaill Fiona,
Muller Sybille,
Kohler Heinz,
Rosenthal Kenneth
Publication year - 2000
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2000.00879.x
Subject(s) - cytotoxic t cell , antibody , human immunodeficiency virus (hiv) , virology , immunology , biology , chemistry , medicine , in vitro , biochemistry
Circulating CD8 + T lymphocyte numbers rise substantially following infection with HIV‐1. This expanded CD8 + T cell population includes HIV‐specific CTL and CTL that kill activated uninfected CD4 + lymphocytes. Experimental, epidemiological and clinical evidence supports the possibility that expansion of CD8 + CTL contributes to CD4 + T cell depletion and disease progression in human HIV infection. Therefore, modulation of CD8 + T cell numbers or of certain CD8 + CTL activated in HIV‐infected individuals may be beneficial. It was found that 1F7, a mAb against an idiotype common to anti‐HIV and anti‐simian immunodeficiency virus (SIV) antibodies, selectively inhibited both anti‐HIV CTL and CTL against uninfected CD4 + T cells. Alloantigen‐specific CTL and NK cells from either HIV‐infected individuals or controls were unaffected by 1F7. Prolonged incubation of CD8 + T cells from HIV‐infected individuals with 1F7 induces apoptosis, which was shown to be reflected functionally in reduced total CTL activity and in especially reduced CTL activity against uninfected CD4 + lymphocytes. The selective reactivity of 1F7 with certain CD8 + CTL could be applied towards the modulation of CD8 + T cell responses involved in AIDS pathogenesis.