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Cross‐presentation of tumour antigens: Evaluation of threshold, duration, distribution and regulation
Author(s) -
Robinson Bruce WS,
Lake Richard A,
Nelson Delia J,
Scott Bernadette A,
Marzo Amanda L
Publication year - 1999
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1999.00876.x
Subject(s) - presentation (obstetrics) , antigen presentation , antigen , immune system , immunology , antigen processing , cross presentation , effector , medicine , biology , t cell , radiology
The development of technology to measure antigen presentation in the secondary lymphoid system has provided the opportunity of analysing components of the host antitumour immune response that have, until now, been unavailable for study. In particular, this technology has enabled us to evaluate threshold levels of tumour antigen required for cross‐presentation in draining lymph nodes, the duration of this antigen presentation and processes that regulate tumour antigen presentation. Thus, we have been able to dissect out the relationship between antigen presentation and the resultant development of effector function in class I‐restricted T cells, as well as the role of regulatory CD4 cells. We have also used this technology to evaluate the effects of antitumour therapy on local antigen cross‐presentation.