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Dendritic cell origins: Puzzles and paradoxes
Author(s) -
Vandenabeele Stéphane,
Wu Li
Publication year - 1999
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1999.00857.x
Subject(s) - dendritic cell , biology , follicular dendritic cells , lineage (genetic) , myeloid , microbiology and biotechnology , immunology , antigen presenting cell , t cell , antigen , immune system , genetics , gene
In the present review, a series of studies on the origins of dendritic cells of mice and humans are summarized. Several subsets of mature dendritic cells found in vivo are described and these may correspond to distinct lineages. There is evidence that some dendritic cells are myeloid‐derived and that others are lymphoid‐derived. The different ways of generating dendritic cells are examined and an attempt to reconcile the differences seen using mouse and human culture models is made. The particular case of Langerhans cells is discussed and an historical overview of the biology of the plasmacytoid T cells, which may represent a distinct ‘lymphoid‐related’ dendritic cell lineage, is given. It is concluded that three or four different pathways lead to the development of different subtypes of dendritic cells.