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Osteoprotegerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development
Author(s) -
Kong YoungYun,
Boyle William J,
Penninger Josef M
Publication year - 1999
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1999.00815.x
Subject(s) - rankl , osteoprotegerin , osteoclast , immune system , lymph node , microbiology and biotechnology , immunology , regulator , lymphocyte , tumor necrosis factor alpha , rank ligand , biology , chemistry , medicine , receptor , activator (genetics) , genetics , gene
The TNF‐family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell–dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.