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The discovery of T cell help for B cell antibody formation: A perspective from the 30th anniversary of this discovery
Author(s) -
Janeway Charles A
Publication year - 1999
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1999.00814.x
Subject(s) - immunology , antibody , antigen , bone marrow , biology , major histocompatibility complex , medicine , microbiology and biotechnology
Thirty years ago, Miller and Mitchell described the bone‐marrow origin of antibody‐forming cells and the thymic origin of the help needed to activate the bone‐marrow‐derived antibody formation. Since then, there has been a continuous stream of discovery in Australia, from Zinkernagel and Doherty's description of MHC‐restricted antigen recognition to Goodnow's dissection of the maturation and tolerization of antigen‐specific B cells. All of these discoveries, and many more described in the text, contribute to the modern synthesis in immunology.