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Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?
Author(s) -
Jaworowski Anthony,
Crowe Suzanne M
Publication year - 1999
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1999.00798.x
Subject(s) - apoptosis , bystander effect , human immunodeficiency virus (hiv) , microbiology and biotechnology , haematopoiesis , programmed cell death , in vivo , immunology , biology , t cell , mechanism (biology) , cell , cancer research , immune system , stem cell , genetics , physics , quantum mechanics
The central pathogenic feature of AIDS is the dramatic loss of CD4+ lymphocytes. Despite more than a decade of intense research, the exact mechanism by which HIV causes this is still not understood. A major model for T cell depletion, proposed originally by Ameison and Capron in a report published in 1991, is that HIV sensitizes CD4+ T cells for activation‐induced apoptosis. The apoptotic model of T cell depletion is discussed, and experiments that address the questions of whether apoptosis is restricted to infected cells or ‘bystander’ T cells, and whether T cell apoptosis requires participation of separate HIV‐infected haematopoietic cell populations, are reviewed.