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MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response
Author(s) -
Lake Richard A,
Robinson Bruce W S,
Hayball John D
Publication year - 1999
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1999.00794.x
Subject(s) - immune system , microbiology and biotechnology , ligand (biochemistry) , antigen , mhc class i , cell , event (particle physics) , t cell , major histocompatibility complex , biology , chemistry , immunology , receptor , genetics , physics , quantum mechanics
Class II multimer formation is an important event in immune recognition. Not only is multimerization a prerequisite for T cell activation, but it is a signal to APC. In the present article, we propose that multimerization can result in the specific removal of ligand complexes from the cell surface of the APC, an event which may influence the overall pattern of T cell reactivity.