Premium
Cellular and molecular regulation of eosinophil trafficking to the lung
Author(s) -
Hogan Simon P,
Mould Arne W,
Young Janine M,
Rothenberg Marc E,
Ramsay Alistair J,
Matthaei Klaus,
Young Ian G,
Foster Paul S
Publication year - 1998
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1998.00766.x
Subject(s) - eosinophil , eosinophilia , asthma , pathogenesis , immunology , lung , pulmonary eosinophilia , inflammation , medicine , biology
Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4 + T cells and IL‐5‐driven eosinophilia as potential targets for the relief of bronchial hyperractivity in late‐phase asthma.