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Characteristics of the immunological response in the clearance of non‐typeable Haemophilus influenzae from the lung
Author(s) -
Foxwell A Ruth,
Kyd Jennelle M,
Cripps Allan W
Publication year - 1998
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.1998.00740.x
Subject(s) - immune system , haemophilus influenzae , immunology , respiratory tract , lung , immunization , pasteurellaceae , mucociliary clearance , biology , microbiology and biotechnology , respiratory tract infections , respiratory system , medicine , antibiotics , anatomy
Clearance of non‐typeable Haemophilus influenzae (NTHi) from the respiratory tract was investigated, over time, in immune and non‐immune rats. A triphasic pattern characterized the clearance of bacteria from the lungs. Mucosal immunization enhanced bacterial clearance from the lungs in each of the three phases compared with clearance from non‐immunized animals. Total clearance of bacteria was observed from lung tissue by 12 h in immune animals and 24 h in non‐immune animals. Polymorphonuclear leucocytes not only arrived earlier and initially in greater numbers, but disappeared earlier in immune animals (peaking at 8 h post‐challenge), compared with non‐immune animals (peaking at 12 h post‐challenge). Systemically derived and locally produced NTHi‐specific IgA and IgG correlated with enhanced bacterial clearance during the secondary phase. This model demonstrates that immunized animals up‐regulate and resolve inflammatory responses to pulmonary infection more rapidly than the non‐immunized controls.