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Expression and role of retinoic acid receptor alpha in lens regeneration
Author(s) -
Tsonis Panagiotis A.,
Tsavaris Melissa,
Call Mindy K.,
Chandraratna Roshantha A. S.,
Del RioTsonis Katia
Publication year - 2002
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1046/j.1440-169x.2002.00652.x
Subject(s) - retinoic acid , lens (geology) , biology , regeneration (biology) , microbiology and biotechnology , retinoic acid receptor , lens fiber , morphogenesis , antagonist , retinoic acid receptor alpha , receptor , retinoid , retinoic acid inducible orphan g protein coupled receptor , function (biology) , alpha (finance) , retinoic acid receptor gamma , biochemistry , gene , medicine , paleontology , construct validity , nursing , patient satisfaction
The role of retinoids in eye development has been well studied. Retinoids and their receptors regulate gene expression and morphogenesis of the eye. In this study, a highly specific antagonist of retinoic acid receptor (RAR)‐α was used in an attempt to study its function in lens regeneration. It was found that this antagonist inhibited lens regeneration and lens fiber differentiation. It was also shown that RAR‐α is expressed in the lens during the process of regeneration. These results indicate that different RAR might have unique as well as redundant effects and patterns of expression in the regenerating lens.