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Possible roles of β ‐catenin in evagination of the optic primordium in rat embryos
Author(s) -
Matsuda Motoko,
Keino Hiroomi
Publication year - 2001
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1046/j.1440-169x.2001.00586.x
Subject(s) - primordium , optic vesicle , microbiology and biotechnology , adherens junction , biology , laminin , microfilament , anatomy , chemistry , eye development , cytoskeleton , cell , extracellular matrix , cadherin , genetics , biochemistry , gene , phenotype
The roles of β‐catenin in evagination of the optic primordium in rat embryos were studied using immunostaining. High levels of β‐catenin appeared transiently in the evaginating optic primordium. Evagination of the optic primordium was suppressed in embryos treated with LiCl. In deficient optic vesicles of these embryos, accumulation of β‐catenin was decreased. Deficient optic vesicles also showed suppression of cyclin D1 accumulation and bromodeoxyuridine incorporation, no break in the deposition of laminin and type IV collagen at the basement membrane (BM) and prevention of the change in distribution of microtubles and microfilaments. These results suggest that β‐catenin regulates cell proliferation, breakdown of BM and changes in cell shape in the evaginating optic primordium to cause optic vesicle formation..