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T‐targets: Clues to understanding the functions of T‐box proteins
Author(s) -
Tada Masazumi,
Smith J. C.
Publication year - 2001
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1046/j.1440-169x.2001.00556.x
Subject(s) - effector , biology , morphogenesis , transcription factor , gene , computational biology , transcription (linguistics) , embryonic stem cell , identification (biology) , genetics , microbiology and biotechnology , ecology , linguistics , philosophy
Members of the T‐box gene family have been identified in both vertebrates and invertebrates, where they play key roles in the regulation of embryonic development, and particularly in morphogenesis and the assignment of cell fate. T‐box proteins act as transcription factors which regulate the expression of downstream effector genes. This review focuses on the identification of T‐box target genes and the basis of T‐box functional specificity.