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Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles
Author(s) -
Iwamasa Hiroko,
Ohta Kunimasa,
Yamada Tomoko,
Ushijima Kazuo,
Terasaki Hidenori,
Tanaka Hideaki
Publication year - 1999
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1046/j.1440-169x.1999.00468.x
Subject(s) - erythropoietin producing hepatocellular (eph) receptor , ephrin , receptor tyrosine kinase , biology , eph receptor a2 , receptor protein tyrosine kinases , embryonic stem cell , microbiology and biotechnology , neuroscience , motor neuron , anatomy , kinase , signal transduction , genetics , gene , spinal cord
Evidence is accumulating that Eph receptor tyrosine kinases and their ligands regulate cell migration and axonal guidance during development. It was previously found that one of the Eph receptors, EphA4, is transiently expressed in subsets of chick embryonic motor neurons. Here, the expression of EphA and ephrin‐A subfamily members was further examined, and the dynamic patterns of expression in chick embryonic motor neurons found. EphA3, EphA4, ephrin‐A2, and ephrin‐A5 were also expressed in the connective tissues of limb muscles and EphA3 and EphA4 expressing motor neurons innervated EphA3 and EphA4 expressing limb muscles, respectively. These spatiotemporal expression patterns suggest that EphA and ephrin‐A proteins play important roles in muscle patterning and motor axonal guidance.