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Neurocardiovascular regulation in mice: Experimental approaches and novel findings
Author(s) -
Ma Xiuying,
Abboud Francois M,
Chapleau Mark W
Publication year - 2003
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2003.03927.x
Subject(s) - neuroscience , blood pressure , disease , function (biology) , reflex , autonomic function , biology , computational biology , bioinformatics , medicine , pathology , endocrinology , microbiology and biotechnology , heart rate , heart rate variability
Summary 1. Neural mechanisms are of major importance in the regulation of arterial blood pressure, blood volume and other aspects of cardiovascular function. The recent explosion in gene discovery and advances in molecular technologies now provide the opportunity to define the molecular and cellular mechanisms essential to integrative neurocardiovascular regulation. The unique susceptibility of mice to genetic manipulation makes this species an attractive model for such investigation. 2. We provide here a brief overview of: (i) experimental approaches used to assess autonomic and reflex control of the circulation in mice; (ii) novel mechanisms of neurocardiovascular regulation revealed using these approaches; and (iii) findings from recent studies involving mouse models of cardiovascular disease.