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Effect Of Kad‐1229, A Novel Hypoglycaemic Agent, On Plasma Glucose Levels After Meal Load In Type 2 Diabetic Rats
Author(s) -
Ichikawa Kiyoshi,
Yamato Tokuhisa,
Ojima Kazuma,
Tsuji Atsutoshi,
Ishikawa Kohtaro,
Kusama Hiroshi,
Kojima Masami
Publication year - 2002
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2002.03682.x
Subject(s) - nateglinide , medicine , meal , endocrinology , plasma glucose , type 2 diabetes , diabetes mellitus , plasma concentration , chemistry
SUMMARY 1. The effects of KAD‐1229 (a novel non‐sulphonylurea agent), voglibose (an α ‐glucosidase inhibitor) and nateglinide (a non‐sulphonylurea antihyperglycaemic agent) on hyperglycaemia induced by a meal load were assessed in diabetic rats. 2. KAD‐1229 suppressed the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUC glucose ) up to 5 h after the meal load. 3. Voglibose also suppressed the increase in plasma glucose levels; however, a significant decrease in AUC glucose following voglibose was not observed. 4. Nateglinide suppressed the increase in plasma glucose levels at 30 min and 1 h after the meal load; however, plasma glucose levels was above control thereafter and the AUC glucose was not decreased. 5. The results indicate that KAD‐1229 has an antihyperglycaemic effect and KAD‐1229 is suggested to be a suitable agent for controlling post‐prandial hyperglycaemia.