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Effects Of Molybdenum, Silicon And Nickel On α 1 ‐Adrenoceptor‐Induced Constriction Of Rat Isolated Aorta
Author(s) -
Liu Dong Ling,
Yan Ming,
Chua Yeow Leng,
Chen Chen,
Lim Yean Leng
Publication year - 2002
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2002.03674.x
Subject(s) - phenylephrine , vasoconstriction , contraction (grammar) , aorta , medicine , chemistry , constriction , endocrinology , agonist , receptor , blood pressure
SUMMARY 1. To determine the effects of trace elements on α 1 ‐adrenoceptor‐mediated vasoconstriction, we studied the effects of molybdenum (Mo), silicon (Si) and nickel (Ni) on vasoconstrictor response to an α 1 ‐adrenoceptor agonist in rat aorta. 2. Cumulative concentration–contraction curves were obtained for phenylephrine (1 nmol/L–10 μ mol/L) in the absence and presence of Mo, Si and Ni (0.3, 1 and 3 μ mol/L) in rat aorta rings. Increasing the concentration of Mo and Si from 0.3 to 3 μ mol/L shifted the cumulative concentration–contraction curve to the right, but did not reduce the maximal contractile response to phenylephrine. In contrast, Ni at 1 and 3 μ mol/L shifted the cumulative concentration–contraction curve to the right and, at 3 μ mol/L, reduced the maximum contractile response to phenylephrine. 3. We conclude that micromolar concentrations of Mo, Si and Ni affected α 1 ‐adrenoceptor‐induced vasoconstriction and that Ni significantly inhibited the maximal contractile response to phenylephrine in rat isolated aorta.