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Role Of Excitatory Amino Acid Inputs To The Rostral Ventrolateral Medulla In Cardiovascular Regulation
Author(s) -
Sved Alan F,
Ito Satoru,
Yajima Yoshiharu
Publication year - 2002
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2002.03663.x
Subject(s) - rostral ventrolateral medulla , excitatory postsynaptic potential , medulla , neuroscience , medulla oblongata , chemistry , medicine , endocrinology , biology , central nervous system , inhibitory postsynaptic potential
SUMMARY 1. Excitatory amino acid (EAA)‐mediated neural transmission in the rostral ventrolateral medulla (RVLM) is important for many cardiovascular reflexes, although the receptor subtypes involved vary depending on the specific response. 2. Although injection of the EAA ionotropic receptor antagonist kynurenic acid into the RVLM has no effect on baseline arterial pressure, this lack of effect appears to result from EAA inputs to RVLM exciting both excitatory and inhibitory mechanisms within the RVLM. 3. The balance between EAA‐mediated excitation and inhibition of RVLM neurons may be shifted to excitation in experimental models of hypertension. 4. The excitatory influence that EAA inputs to the RVLM have on vasomotor neurons in the RVLM may involve a sarthran‐sensitive intermediary in the RVLM.