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Capsazepine Partially Inhibits Neurally Mediated Gastric Mucus Secretion Following Activation Of Protease‐Activated Receptor 2
Author(s) -
Kawabata Atsufumi,
Kinoshita Mitsuhiro,
Kuroda Ryotaro,
Kakehi Kazuaki
Publication year - 2002
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2002.03641.x
Subject(s) - capsazepine , mucus , capsaicin , secretion , receptor , chemistry , receptor antagonist , cytoprotection , medicine , protease activated receptor 2 , endocrinology , antagonist , trpv1 , biology , biochemistry , enzyme linked receptor , apoptosis , transient receptor potential channel , ecology
SUMMARY 1. Protease‐activated receptor 2 (PAR2), present in capsaicin‐sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross‐talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2‐mediated increase in gastric mucus secretion. 3. Thus, activation of VR1 is responsible, at least in part, for the neurally mediated mucosal cytoprotection following activation of PAR2.