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Val‐Tyr As A Natural Antihypertensive Dipeptide Can Be Absorbed Into The Human Circulatory Blood System
Author(s) -
Matsui Toshiro,
Tamaya Kei,
Seki Eiji,
Osajima Katsuhiro,
Matsumoto Kiyoshi,
Kawasaki Terukazu
Publication year - 2002
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2002.03628.x
Subject(s) - dipeptide , chemistry , absorption (acoustics) , circulatory system , bioavailability , pharmacokinetics , plasma concentration , pharmacology , blood plasma , human blood , oral administration , in vivo , human plasma , area under the curve , endocrinology , medicine , chromatography , amino acid , biochemistry , biology , physiology , materials science , microbiology and biotechnology , composite material
SUMMARY 1. Intact absorption of the bioactive dipeptide Val‐Tyr (VY), with in vivo antihypertensive ability in normotensive human subjects, was investigated. 2. As a result of a single oral administration of VY, the VY absorption curve occurred maximally over the second hour postprandially; a greater than 10‐fold higher increment of VY following a dose of 12 mg was observed in the plasma at 2 h compared with the baseline concentration of VY at 0 h (1934 ± 145 vs 159 ± 11 fmol/mL plasma, respectively). 3. Plasma VY levels increased with dose administered (3, 6 and 12 mg), suggesting that exogenous VY could be absorbed intact into the human blood depending on the dose. The elimination half time (t 1 / 2 ) of VY was estimated to be 3.1 h. The area under the curve for the 12 mg VY dose was 9185 ± 688 fmol·h/mL plasma.