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Design Of Clinical Pharmacology Trials
Author(s) -
Duffull Stephen B
Publication year - 2001
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2001.03546.x
Subject(s) - computer science , variety (cybernetics) , clinical trial , drug development , clinical study design , management science , clinical pharmacology , process (computing) , risk analysis (engineering) , pharmacology , medicine , drug , artificial intelligence , engineering , pathology , operating system
SUMMARY 1. There are a variety of methods that could be used to increase the efficiency of the design of experiments. However, it is only recently that such methods have been considered in the design of clinical pharmacology trials. 2. Two such methods, termed data‐dependent (e.g. simulation) and data‐independent (e.g. analytical evaluation of the information in a particular design), are becoming increasingly used as efficient methods for designing clinical trials. These two design methods have tended to be viewed as competitive, although a complementary role in design is proposed here. 3. The impetus for the use of these two methods has been the need for a more fully integrated approach to the drug development process that specifically allows for sequential development (i.e. where the results of early phase studies influence later‐phase studies). 4. The present article briefly presents the background and theory that underpins both the data‐dependent and ‐independent methods with the use of illustrative examples from the literature. In addition, the potential advantages and disadvantages of each method are discussed.