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Dynamic Aspects Of Platelet Adhesion Under Flow
Author(s) -
Dopheide Sacha M,
Yap Cindy L,
Jackson Shaun P
Publication year - 2001
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2001.03468.x
Subject(s) - platelet , integrin , adhesion , microbiology and biotechnology , receptor , von willebrand factor , cell adhesion , cell adhesion molecule , platelet adhesiveness , chemistry , platelet activation , selectin , immunology , platelet membrane glycoprotein , biophysics , biology , biochemistry , platelet aggregation , organic chemistry
SUMMARY 1. Cell–cell and cell–matrix adhesive interactions are critical for a wide range of physiological processes, including embryogenesis, inflammation, immunity and haemostasis. 2. The ability of circulating blood cells, such as platelets and leucocytes, to adhere to sites of vascular injury is complicated by the presence of blood flow, which imposes hydrodynamic forces on adhesion contacts. 3. To overcome this problem, platelets and leucocytes have evolved specific adhesion receptors with unique biomechanical properties that enable these cells to adhere to the vessel wall under flow conditions. 4. Platelet adhesion in the normal circulation appears to be a multiple‐step process involving an initial reversible interaction between the platelet adhesion receptor glycoprotein Ib‐IX‐V and the vascular adhesion protein von Willebrand factor. Once tethered to the vessel wall, platelets form irreversible adhesion contacts through the binding of one or more platelet integrins to specific subendothelial matrix proteins. 5. There is now a wealth of evidence demonstrating that these receptors not only mediate platelet adhesion, but also transduce signals leading to platelet activation. 6. In the present review, we will briefly discuss the current understanding of the specific roles of individual platelet receptors in supporting the haemostatic function of platelets and discuss mechanisms by which these receptors induce platelet activation.