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Allosteric Modulation of the Gaba A Receptor In Rat Hypothalamus By Somatostatin Is Altered By Stress
Author(s) -
Chigr F,
M'Hamed S Ba,
Najimi M
Publication year - 2001
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2001.03447.x
Subject(s) - somatostatin , hypothalamus , somatostatin receptor , allosteric regulation , medicine , endocrinology , receptor , chemistry , somatostatin receptor 2 , gabaa receptor , somatostatin receptor 1 , somatostatin receptor 3 , gaba receptor , biology , biochemistry
SUMMARY 1. This autoradiographic study was conducted to investigate somatostatin modulation of GABA A receptor binding in hypothalamic structures of immobilization‐stressed rats. 2. GABA A receptor binding was labelled with [ 35 S]‐t‐ butylbicyclophosphorothionate (TBPS), which binds in or near the chloride channel. 3. Several structures of the rat hypothalamus (i.e. the peri‐ and paraventricular nuclei) display an increase in [ 35 S]‐TBPS binding as well as an alteration of the modulatory effect of somatostatin on the GABA A receptor complex under stress. Furthermore, these results demonstrate for the first time that somatostatin is particularly effective in modifying [ 35 S]‐TBPS binding to the GABA A receptor in rat hypothalamus.