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Subarachnoid Haemorrhage‐Induced Sympathoexcitation In Rats Is Reversed By Bosentan Or Sodium Nitroprusside
Author(s) -
Lambert Gavin,
Lambert Elisabeth,
Fassot Céline,
Friberg Peter,
Elghozi JeanLuc
Publication year - 2001
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2001.03427.x
Subject(s) - sodium nitroprusside , bosentan , medicine , blood pressure , anesthesia , endothelin receptor , sympathetic nervous system , endothelin receptor antagonist , nitric oxide , subarachnoid hemorrhage , receptor
SUMMARY 1. The roles played by nitric oxide (NO) and endothelin (ET) in the genesis of sympathetic nervous activation following experimental subarachnoid haemorrhage was investigated using spectral analysis of blood pressure rhythms. 2. Subarachnoid haemorrhage was induced in conscious rats by injecting 0.3 mL homologous blood via a catheter placed along the surface of the brain and directed towards the circle of Willis. Three hours after the insult and after sympathetic activation was evident, animals received either an acute injection of the ET antagonist bosentan (5 mg/kg, i.v.; n = 7), an infusion of the NO donor sodium nitroprusside (SNP; 18 μg/h; n = 7) or no treatment ( n = 7). 3. Three hours following the induction of subarachnoid haemorrhage, the mid‐frequency components of systolic blood pressure were markedly elevated, indicating a pronounced sympathoexcitation. However, blood pressure and heart rate levels remained unchanged at this time. In the absence of treatment, the mid‐frequency components of blood pressure remained elevated for a subsequent 2 h. Treatment with a non‐hypotensive dose of SNP reversed the sympathoexcitation within 1 h. Treatment with bosentan was also effective in reducing the mid‐frequency oscillations in blood pressure associated with subarachnoid haemorrhage. 4. Our results indicate that subarachnoid haemorrhage is associated with an acute activation of the sympathetic nervous system. The degree of sympathoexcitation can be reversed by the use of either bosentan or SNP.