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Experimental Biology 2000 Symposium on Differential Control of Sympathetic Outflow DIFFERENTIAL PATTERNS OF SYMPATHETIC RESPONSES TO SELECTIVE STIMULATION OF NUCLEUS TRACTUS SOLITARIUS PURINERGIC RECEPTOR SUBTYPES
Author(s) -
Scislo Tadeusz J,
Kitchen Amy M,
Augustyniak Robert A,
O'Leary Donal S
Publication year - 2001
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2001.03404.x
Subject(s) - purinergic receptor , stimulation , endocrinology , sympathetic nervous system , chemistry , receptor , medicine , sympathoadrenal system , neuroscience , autonomic nervous system , biology , catecholamine , heart rate , blood pressure
SUMMARY 1. Studies are described that indicate that stimulation of different purinergic receptor subtypes (A 1 , A 2A and P2X) located in the sub‐postremal nucleus tractus solitarius (NTS) evokes qualitatively and quantitatively different regional haemodynamic and efferent sympathetic responses. 2. Stimulation of A 2A receptors evoked the most diverse pattern of regional sympathetic responses: preganglionic adrenal nerve activity (pre‐ASNA) was increased, lumbar sympathetic nerve activity (LSNA) did not change, while renal (RSNA) and post‐ganglionic adrenal (post‐ASNA) sympathetic nerve activity was decreased. Stimulation of A 1 receptors evoked qualitatively uniform, although quantitatively different, sympathoactivation: ↑pre‐ASNA > ↑RSNA >↑LSNA. Stimulation of P2X receptors evoked qualitatively uniform, although quantitatively different, sympathoinhibition: ↓RSNA = ↓post‐ASNA > ↓LSNA = ↓pre‐ASNA. 3. These qualitatively and quantitatively different patterns of regional sympathetic responses strongly suggest that purinergic receptor subtypes may be specifically located and differentially expressed on NTS neurons/neural terminals that control different sympathetic outputs. Different NTS purinoceptors may contribute to patterned autonomic responses observed in specific physiological or pathological situations.