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Proceedings of the Australian Neuroscience Society Symposium: Schizophrenia A PROPOSED PATHOLOGICAL MODEL IN THE HIPPOCAMPUS OF SUBJECTS WITH SCHIZOPHRENIA
Author(s) -
Scarr E,
Dean B
Publication year - 2001
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2001.03400.x
Subject(s) - neuroscience , hippocampal formation , schizophrenia (object oriented programming) , hippocampus , dopamine , serotonergic , dopamine hypothesis of schizophrenia , psychology , neurotransmitter , glutamatergic , neurotransmission , clozapine , psychiatry , dopaminergic , medicine , glutamate receptor , serotonin , central nervous system , receptor
SUMMARY 1. The hippocampal formation plays an important role in the normal functioning of the brain, being implicated in cognition and sensory gating, both of which are affected in schizophrenia. The hippocampal formation receives information from the association cortices, which is processed by glutamatergic transmission within the hippocampus. Dopamine, noradrenaline, 5‐hydroxytryptamine (5‐HT), acetylcholine and GABA, all of which have been proposed to play a role in the neurobiology of schizophrenia, can affect this transmission. 2. The advent of the ‘atypical’ antipsychotics, with their broad pharmacological spectra and improved therapeutic outcome, has revitalized research into neurotransmitter dysfunction other than that of dopamine. In particular, there has been interest in the serotonergic and cholinergic systems within the hippocampal formation because these are two of the transmitter systems targeted by clozapine and olanzapine. 3. From the study of these systems, using tissue obtained post‐mortem from subjects with schizophrenia, we propose that there is a hyperserotonergic state in the hippocampal formation of some subjects with schizophrenia caused by a conformational change in the 5‐HT transporter. The model we propose allows us to construct further studies that will test the consequences of such a hyperserotonergic state in the hippocampal formation. This model has the potential to open new avenues in schizophrenia research.