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High Plasma Concentrations Of Prorenin In A Transgenic Animal Model Of Nephropathy With Overexpression Of Transforming Growth Factor‐β1 In The Kidneys
Author(s) -
Krag Søren,
Nielsen Arne Høj,
Wogensen Lise
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03330.x
Subject(s) - endocrinology , medicine , transgene , transforming growth factor , nephropathy , genetically modified mouse , diabetic nephropathy , secretion , biology , kidney , chemistry , diabetes mellitus , gene , biochemistry
SUMMARY 1. Plasma concentrations of prorenin were determined in a transgenic animal model of nephropathy induced by overexpression of transforming growth factor (TGF)‐β1 in the juxtaglomerular apparatus. 2. In both female and male mice, plasma concentrations of prorenin were higher in transgenic than in non‐transgenic animals. In sexually mature mice, plasma prorenin concentrations were higher in males than in females in both transgenic and non‐transgenic animals in accordance with a sexual dimorphism of the plasma concentration of prorenin. 3. The results indicate that TGF‐β1‐like androgens increase prorenin secretion in the kidneys and may explain the increased plasma prorenin concentrations in patients with diabetic nephropathy.