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Physiological Effects Of Extracellular Nucleotides In The Inner Ear
Author(s) -
Housley Gary D
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03314.x
Subject(s) - ionotropic effect , cochlea , signal transduction , extracellular , inner ear , metabotropic receptor , transduction (biophysics) , purinergic signalling , microbiology and biotechnology , biology , receptor , neuroscience , neurotransmission , purinergic receptor , p2y receptor , chemistry , biochemistry , adenosine receptor , glutamate receptor , agonist
SUMMARY 1. Electrochemical homeostasis, sound transduction and auditory neurotransmission in the cochlea are influenced by extracellular purines and pyrimidines. 2. Evidence that ATP and related nucleotides influence inner ear function arises from a considerable number of cellular, molecular and physiological studies in vitro and in vivo . 3. With a full understanding of these processes, which include ionotropic (P2X receptor) and metabotropic (P2Y receptor) signal transduction pathways, signal termination involving ecto‐nucleotidases and recycling via nucleoside transporters, exciting possibilities emerge for treating hearing disorders, such as Menière’s disease, tinnitus and sensorineural deafness.