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Carotid Artery Intima–Medial Thickness Is Increased In Chronic Renal Failure
Author(s) -
Zoungas Sophia,
Ristevski Sonya,
Lightfoot Paul,
Liang YuLu,
Branley Pauline,
Shiel Louise M,
Kerr Peter,
Atkins Robert,
McNeil John J,
McGrath Barry P
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03301.x
Subject(s) - medicine , cardiology , homocysteine , intima media thickness , common carotid artery , creatinine , endocrinology , blood pressure , ultrasound , pulse pressure , pulse wave velocity , carotid arteries , cohort , radiology
SUMMARY 1. Chronic renal failure (CRF) is associated with rapidly progressive atherosclerotic vascular disease. In the present study, carotid arterial intima–medial thickness (IMT) was assessed in a large cohort of patients with CRF and matched controls and related to risk factors. 2. A total of 159 subjects with CRF (serum creatinine ≥ 0.40 mmol/L) aged > 50 years (mean (±SD) 63.8±7.7 years) and 159 healthy controls matched for age, sex and smoking status were studied. 3. The IMT was determined using B‐mode ultrasound measurements of the far wall of both common carotid arteries and presented as the mean IMT. Fasting plasma homocysteine (tHcy) was measured in the CRF group. 4. Intima–medial thickness was significantly greater in CRF patients than controls (0.89±0.17 vs 0.73±0.13 mm, respectively) after matching for age, sex and smoking status. Heart rate and pulse pressure were also significantly increased. The tHcy was increased two‐fold in the CRF group (27.7±11.3 μmol/L; normal < 13.0 μmol/L) and did not correlate with carotid IMT. 5. Compared with controls after adjusting for traditional risk factors, patients with CRF exhibit significantly increased IMT.