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Type‐C Natriuretic Peptide Prevents Development Of Experimental Atherosclerosis In Rabbits
Author(s) -
Gaspari Tracey A,
Barber Melissa N,
Woods Robyn L,
Dusting Gregory J
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03297.x
Subject(s) - neointima , natriuretic peptide , medicine , atheroma , endocrinology , saline , endothelium , contraction (grammar) , endothelial dysfunction , acetylcholine , cardiology , stent , restenosis , heart failure
SUMMARY 1. We investigated the effect of local administration of type‐C natriuretic peptide (CNP) on the endothelial dysfunction and development of an atheroma‐like neointima induced by a peri‐arterial collar in rabbits. 2. Peri‐arterial collars were placed on both common carotid arteries allowing local treatment of the collared region with either CNP (10 μmol/L) or saline. After 7 days, uncollared (control) and collared sections were taken from both arteries for pharmacological and morphological analysis. 3. Application of the collar markedly attenuated ( P < 0.05) endothelium‐dependent vasorelaxation induced by acetylcholine (ACh); inhibition of 5‐hydroxytryptamine contraction was 80±5% in control sections compared with 44±4% in collared sections from the same arteries. Local infusion of CNP (10 μmol/L) into the collar restored ACh‐induced vasorelaxation (74±3% from collared arteries + CNP vs 77±2% from control sections from the same arteries). 4. Type‐C natriuretic peptide treatment also reduced ( P < 0.05) intimal thickening compared with contralateral collared arteries (intima/media ratio 0.06±0.01 vs 0.16±0.01). 5. These results provide evidence that locally administered CNP is effective in preventing the endothelial dysfunction and development of a neointima in this model.