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Role Of Neurotrophin Receptor p75NTR In Mediating Neuronal Cell Death Following Injury
Author(s) -
Coulson Ej,
Reid K,
Murray Ss,
Cheema Ss,
Bartlett Pf
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03295.x
Subject(s) - low affinity nerve growth factor receptor , programmed cell death , neurotrophin , nerve growth factor , microbiology and biotechnology , receptor , caspase , tropomyosin receptor kinase a , neurotrophin 3 , apoptosis , biology , neuroscience , neurotrophic factors , brain derived neurotrophic factor , biochemistry
SUMMARY 1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down‐regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor κB and c‐jun), Bcl‐2 family members and caspases.