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Effects Of NKH477 On Endothelin‐1‐Induced Renal Responses In Anaesthetized Dogs
Author(s) -
Hara Sunao,
Tanahashi Masayuki,
Yoshida Makoto,
SuzukiKusaba Mizue,
Hisa Hiroaki,
Satoh Susumu
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03282.x
Subject(s) - renal blood flow , renal function , endothelin receptor , endocrinology , medicine , effective renal plasma flow , chemistry , kidney , urine flow rate , urinary system , renal physiology , excretion , receptor
SUMMARY 1. Intrarenal arterial infusion of a direct adenylate cyclase activator (NKH477; 300 ng/kg per min) increased renal blood flow, urine flow rate and urinary sodium excretion in anaesthetized dogs. 2. Intrarenal arterial infusion of endothelin (ET)‐1 (2 ng/kg per min) reduced basal values of these parameters and glomerular filtration rate, which were recovered by the addition of NKH477 during ET‐1 infusion. 3. These results demonstrate that NKH477 can counteract ET‐1‐induced antinatriuresis, mainly by restoring glomerular filtration.