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Ginkgo Biloba Extract Attenuates The Development Of Hypertension In Deoxycorticosterone Acetate‐Salt Hypertensive Rats
Author(s) -
Umegaki Keizo,
Shinozuka Kazumasa,
Watarai Ken,
Takenaka Hiroyuki,
Yoshimura Mika,
Daohua Pang,
Esashi Takatoshi
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03236.x
Subject(s) - ginkgo biloba , endocrinology , medicine , blood pressure , heart rate , chemistry , pharmacology
SUMMARY 1. We examined the effects of Ginkgo biloba extract (GBE) on the development of hypertension, platelet activation and renal dysfunction in deoxycorticosterone acetate (DOCA)‐ salt hypertensive rats. Both DOCA‐salt hypertensive rats and normotensive rats were fed a 2% GBE diet for 20 days. Blood pressure (BP) was measured by two methods, namely by the tail‐cuff and telemetry methods. 2. Development of hypertension was attenuated in rats fed a 2% GBE diet. In addition, an increase in heart weight, an indicator of sustained high BP, was inhibited significantly by feeding of the GBE diet. 3. Decreases in 5‐hydroxytryptamine content in platelets, a marker of platelet activation in vivo associated with hypertension, were also prevented by feeding of the GBE diet. Ginkgo biloba extract itself did not inhibit ADP‐ and collagen‐induced platelet aggregation examined in vitro . Feeding of the GBE diet tended to inhibit increases in plasma urea nitrogen due to hypertension. 4. The telemetry study demonstrated that BP and heart rate (HR) showed a clear circadian rhythm and the anti‐ hypertensive effect of GBE was prominent in the daytime, a resting period for rats. This anti‐hypertensive effect of GBE was not detected in normotensive rats. In contrast, the inhibitory effect of GBE on HR was independent of time and was observed in both normotensive and hypertensive rats. 5. These results indicate that GBE has an anti‐hypertensive and bradycardiac action, which are time dependent and independent, respectively. Thus, it appears that the chronopharmacological action of GBE may be ascribed not to pharmacokinetic factors, but rather to a circadian susceptibility rhythm to GBE in DOCA‐salt hypertensive rats.