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Formation Of The Aqueous Humor
Author(s) -
Macknight Anthony Dc,
McLaughlin Charles W,
Peart David,
Purves Robert D,
Carré David A,
Civan Mortimer M
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03208.x
Subject(s) - glaucoma , intraocular pressure , secretion , aqueous humor , population , blindness , ophthalmology , ciliary body , chemistry , in vitro , microbiology and biotechnology , biology , medicine , biochemistry , optometry , environmental health
SUMMARY 1. Glaucoma is a worldwide disease affecting approximately 1–2% of the population aged over 35 years in industrial countries and is a major cause of blindness. 2. Glaucoma is usually associated with an increased intra‐ocular pressure reflecting an imbalance between the rate of production of fluid (the aqueous humor) by the ciliary epithelial cells and its drainage from the eye. Therefore, it is important to understand how this secretion is produced. This requires a knowledge of ciliary epithelial cell composition, which has, in the past, proved difficult to obtain in mammalian preparations. 3. We have recently used the technique of electron‐probe X‐ray microanalysis to determine this composition under a variety of in vitro conditions. 4. Our results have led to a new model for this secretion that emphasizes the potential secretory role of the Na + /K + /2Cl – cotransporter.