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Troponin T In The Coronary Sinus And Percutaneous Transluminal Coronary Angioplasty Related Myocardial Injury
Author(s) -
Katoh Harumi,
Shimada Toshio,
Sano Kazuya,
Inoue Shinichi,
Kitamura Jun,
Sakane Takeshi,
Murakami Yo,
Ishibashi Yutaka,
Karino Kenji,
Masuda Junichi
Publication year - 2000
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.2000.03196.x
Subject(s) - medicine , cardiology , troponin complex , coronary sinus , angioplasty , troponin t , artery , chest pain , great cardiac vein , angina , troponin , myocardial infarction
SUMMARY 1. Myocardial injury has been shown to be associated with successful percutaneous transluminal coronary angioplasty (PTCA). The present study was designed to determine whether uncomplicated successful PTCA results in myocardial injury by measuring coronary sinus (CS) cardiac troponin T (cTnT). 2. We measured cTnT in the CS and the femoral vein (FV) in 16 patients with stable angina pectoris who underwent uncomplicated PTCA for stenotic lesions of the left anterior descending artery. Blood samples were drawn from both the CS and FV before and immediately after PTCA and every 4 h for the next 12 h. 3. All patients had chest pain and electrocardiographic ST segment elevation or depression during balloon inflation and higher peak elevation of cTnT in the CS than in the FV (0.054±0.059 vs 0.036±0.022 ng/mL; P < 0.05). However, all CS cTnT levels were within the normal range over the 12 h period. 4. The fact that CS cTnT measurements showed no evidence of uncomplicated PTCA‐related myocardial injury led us to conclude that uncomplicated successful PTCA does not cause myocardial injury.