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ENDOTHELIN AND POST‐GANGLIONIC SYMPATHETIC NEURONS
Author(s) -
Damon Deborah H
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03179.x
Subject(s) - endothelin receptor , medicine , endocrinology , neurotransmitter , nerve growth factor , sympathetic nerve , endothelin 1 , sympathetic nervous system , neuroscience , mediator , receptor , biology , blood pressure
SUMMARY 1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post‐ganglionic sympathetic neuronal development. 2. Endothelin is produced by post‐ganglionic neurons and by cells adjacent to these neurons. 3. Post‐ganglionic sympathetic neurons express functional receptors for ET. 4. Endothelin promotes the survival of cultured post‐ ganglionic sympathetic neurons and modulates the morphological and biochemical differentiation of these neurons. 5. Endothelin enhances the activity of nerve growth factor and modulates the release of neurotransmitter from post‐ ganglionic sympathetic nerve terminals.