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INHIBITORY EFFECT OF NITRIC OXIDE ON THE RENIN–ANGIOTENSIN SYSTEM IN DAHL SALT‐SENSITIVE RATS
Author(s) -
Kasuya Akira,
Satoh Sachi,
Yoshida Makoto,
Hisa Hiroaki,
SuzukiKusaba Mizue,
Satoh Susumu
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03160.x
Subject(s) - renin–angiotensin system , nitric oxide , medicine , endocrinology , chemistry , angiotensin ii , plasma renin activity , arginine , kidney , aorta , blood pressure , biochemistry , amino acid
SUMMARY 1. To explore the role of nitric oxide (NO) in the regulation of the renin–angiotensin system (RAS) in Dahl salt‐sensitive (DS) rats, the effects of N G ‐nitro‐ L ‐arginine methyl ester ( L ‐NAME) on plasma renin activity (PRA), and concentrations of angiotensin (Ang)I and AngII in the plasma, aorta and kidney were investigated in DS and Dahl salt‐resistant (DR) rats. 2. N G ‐Nitro‐ L ‐arginine methyl ester (12–18 mg/kg per day) administration for 1 week increased mean arterial pressure (MAP) in DS and DR rats fed a 0.3% NaCl diet and in DR rats fed an 8% NaCl diet compared with corresponding vehicle (water)‐treated groups. However, L ‐NAME administration did not change MAP in DS rats fed an 8% NaCl diet. 3. N G ‐Nitro‐ L ‐arginine methyl ester administration increased PRA in DS rats fed an 8% NaCl diet, but not in DR rats fed an 8% NaCl diet. N G ‐Nitro‐ L ‐arginine methyl ester administration increased AngI and AngII concentrations in plasma, aorta and kidney only in DS rats fed an 8% NaCl diet. The ratio of AngI to AngII did not change following L ‐NAME administration in any rats. 4. These results suggest that NO has an inhibitory role on renin release in DS rats fed a high‐salt diet.