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PROLONGED HYPOXIC STRESS INCREASES ADRENAL CHOLESTEROL RESERVE IN RATS WITHOUT CAUSING ADRENAL HYPERTROPHY
Author(s) -
Cheng Behling,
Abraham Susamma,
Thakkar Jitendra,
Kowal Jerome
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03153.x
Subject(s) - medicine , endocrinology , muscle hypertrophy , hypoxia (environmental) , chemistry , oxygen , organic chemistry
SUMMARY 1. It is known that, in rats, hypoxia stimulates adrenal steroidogenesis, but our understanding of the hypoxic effect on the glandular parameters remains incomplete. 2. Adrenals were collected and analysed from rats that had been exposed to hypoxic conditions for 3 weeks. 3. The results reveal increased adrenal concentrations of corticosterone, free cholesterol and total cholesterol without a change in glandular weight and protein concentration. The increased total cholesterol is primarily associated with enriched cholesteryl adrenate (CE22 : 4), cholesteryl arachidonate (CE20 : 4) and cholesteryl oleate (CE18 : 1).