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DISTRIBUTION OF GABA A AND GLYCINE RECEPTORS IN THE MAMMALIAN RETINA
Author(s) -
Grünert Ulrike
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03152.x
Subject(s) - glycine receptor , gabaa receptor , receptor , gabaa rho receptor , neurotransmitter receptor , class c gpcr , neurotransmitter , immunocytochemistry , glycine , cys loop receptors , biology , microbiology and biotechnology , retina , rhodopsin like receptors , neuroscience , protein subunit , inhibitory postsynaptic potential , neurotransmission , biochemistry , metabotropic receptor , endocrinology , amino acid , glutamate receptor , acetylcholine receptor , gene , nicotinic acetylcholine receptor
SUMMARY 1. GABA and glycine mediate synaptic inhibition via specific neurotransmitter receptors. Molecular cloning studies have shown that there is a great diversity of receptors for these two neurotransmitters. In the present paper, the distribution of GABA A and glycine receptors in the mammalian retina is reviewed. 2. In situ hybridization, immunocytochemistry with subunit‐specific antibodies and single cell injection were used to analyse the localization of receptor subunits. Specific subunits are expressed in characteristic strata of the inner plexiform layer, suggesting that different functional circuits involve specific subtypes of neurotransmitter receptors. 3. Different cell types express different combinations of receptor subunits and an individual neuron can express several receptor isoforms at distinct post‐synaptic sites.