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ANALYSIS IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Nara Y,
Mashimo T,
Tamada T,
Matsumoto C,
Ishinaga Y,
Nabika T,
Ikeda K,
Sawamura M,
Yamori Y
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03089.x
Subject(s) - medicine , cardiology
1. Linkage analysis is performed between basal or salt‐ sensitive high blood pressure and several loci on chromosomes in F2 progenies obtained from crossing stroke‐prone spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto rats. 2. Basal hypertensive genes are mapped to a region near the D1Mit2 locus on chromosome 1 and near the D3Mgh8 locus on chromosome 3 in the male and female F2 progenies. 3. Salt‐sensitive hypertensive gene is mapped to a region near RR1023 locus on chromosome 10 in the male F2 progenies. 4. Salt‐sensitive hypertensive gene is mapped to a region near D3Mgh12 locus on chromosome 3 in the female F2 progenies.