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SARCOPLASMIC RETICULUM IN VASCULAR CELLS IN HYPERTENSION AND DURING PROLIFERATION
Author(s) -
Lompré AnneMarie
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03079.x
Subject(s) - serca , endoplasmic reticulum , ryanodine receptor , vascular smooth muscle , medicine , endocrinology , chemistry , inositol trisphosphate receptor , intracellular , receptor , inositol , microbiology and biotechnology , atpase , biology , smooth muscle , biochemistry , enzyme
1. Multiple sarco(endo)plasmic reticulum Ca 2+ ‐ATPase (SERCA) and two types of sarcoplasmic reticulum Ca 2+ channels, the ryanodine receptor and the inositol 1,4,5 triphosphate (IP3) receptor are expressed. The heterogeneity of the Ca 2+ pumps and Ca 2+ channels in vascular cells will be discussed. 2. An age‐related change in expression of the SERCA isoforms is observed in smooth muscle cells. 3. The sarcoplasmic reticulum Ca 2+ ‐uptake rate and the level of SERCA 2 mRNA are different in thoracic than in abdominal aortas and in aortas from spontaneously hypertensive rats than from normotensive rats. 4. Proliferation of vascular smooth muscle cells is associated with major changes in intracellular Ca 2+ ‐handling mechanisms.