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THE A1166C MUTATION IN THE ANGIOTENSIN II TYPE I RECEPTOR AND HYPERTENSION IN THE ELDERLY
Author(s) -
Liyou Nancy,
Davis Darren,
James Kristy,
Simons Leon,
Friedlander Yechiel,
Simons Judith,
McCallum John,
Johnson Anthony
Publication year - 1999
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1046/j.1440-1681.1999.03066.x
Subject(s) - angiotensin ii , angiotensin ii receptor type 1 , medicine , mutation , endocrinology , renin–angiotensin system , cardiology , receptor , genetics , biology , blood pressure , gene
1. Using a nested case‐control study of 661 non‐institutionalized elderly (≥ 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT 1 ) receptor gene is associated with hypertension in the elderly. 2. Individuals were classified as isolated systolic hypertension (ISH, n = 146), systolic diastolic hypertension (SDH, n = 188), or normotensive, age‐ and sex‐matched controls ( n = 327). AA, CC and AC genotypes were determined using restriction fragment length polymorphism analysis of DNA generated by nested polymerase chain reaction. 3. A univariate analysis (χ 2 ) was complemented by a logistic regression analysis, facilitating adjustment for potential confounders. The unadjusted genotype and allele frequencies in ISH or SDH subjects did not differ significantly from the control subjects (χ 2 = 3.0, P = 0.55, 4 d.f.; χ 2 = 3.0, P = 0.23, 2 d.f., respectively). After adjustment for potential confounders neither genotype nor allele predicted ISH or SDH in this cohort. 4. From this study we conclude that the A1166C polymorphism of the AT 1 receptor gene is not a marker for ISH nor for SDH in this large, elderly community sample.